what is Sulfaguanidinen
ulfanilamide and sulphaamidine used to be commonly used as sulfanilamide drugs. Due to their greater toxicity, they are generally not used as the first choice. Now they and paracetaminobenzene sulfonyl chloride are only used as intermediates in the production of sulfanilamide drugs.Sulphaamidine, also known as sulphaguanidine, zhilitong tablets, the earliest used for intestinal infection of sulphaidine, sulphaamidine molecular structure has strong basic guanidine, the degree of dissociation, fat solubility is small, although there is a certain amount of absorption from the intestinal tract, but not enough to reach the effective blood concentration, so it is not used for systemic infection. However, it can maintain a high concentration in the intestine and is used for bacterial infections of the digestive tract. Such as gastroenteritis, dysentery, etc.
Testing Item |
Standard |
Result |
Conclusion |
Appearance |
White or almost white crystalline or powder |
Complies |
Complies |
Identification |
Pass IR positive reaction |
Conform |
Complies |
Loss on drying |
6.0% ~ 8.0% |
7.70% |
Complies |
Heavy Metal(ppm) |
≤ 20ppm |
< 10ppm |
Complies |
Melting Point |
189°C ~ 192°C |
189.8°C ~ 192.0°C |
Complies |
Chloride |
≤ 100ppm |
< 100ppm |
Complies |
Sulphate Ash |
≤ 0.1% |
0.05% |
Complies |
Related Substance |
≤ 0.5% |
< 0.5% |
Complies |
Assay |
99.0% ~ 101.0% |
99.67% |
Complies |
CONCLUSION |
Comply with BPV95 Standard. |
Common Name |
Sulfaguanidine |
CAS Number |
57-67-0 |
Molecular Weight |
214.245 |
Density |
1.6±0.1 g/cm3 |
Boiling Point |
426.1±47.0 °C at 760 mmHg |
Molecular Formula |
C7H10N4O2S |
Melting Point |
190-193°C |
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